Isochronic tones are the most recent and advanced method for brainwave entrainment audios. With isochronic tones, the same intensity is used for all tones, but they pulsate on and off at different rates. The speed, pattern, and rates of these tones can be changed and altered throughout the recording, and the brain will follow them into desired states. The use of isochronic tones opens up the ability to lead the brain into highly specific states, at specific speeds and intensities. This has opened up the doorway to producing both dominant and subdominant waves(i.e. an alpha brainwave state with subdominant theta waves), and the ability to lead the brain through different waves, at specific speeds (i.e. holding the brain in an alpha state for 10 minutes, then dropping it through theta for 20, and holding it in delta for five before bringing it back into alpha at the end of the recording.) This allows thousands of different possibilities in training the brain, and also makes the process of listening to these types of audios more natural, and more powerful. 
Brainwave entrainment is a colloquialism for such 'neural entrainment', which is a term used to denote the way in which the aggregate frequency of oscillations produced by the synchronous electrical activity in ensembles of cortical neurons can adjust to synchronize with the periodic vibration of an external stimuli, such as a sustained acoustic frequency perceived as pitch, a regularly repeating pattern of intermittent sounds, perceived as rhythm, or of a regularly rhythmically intermittent flashing light.
The Frequency following response (FFR), also referred to as Frequency Following Potential (FFP), is a specific response to hearing sound and music, by which neural oscillations adjust their frequency to match the rhythm of auditory stimuli. The use of sound with intent to influence cortical brainwave frequency is called auditory driving,[39][40] by which frequency of neural oscillation is 'driven' to entrain with that of the rhythm of a sound source.[41][42]
With regard to that, I would like to tell you a story about GMO. I recently explored a case study about GMO products, which explained how initial research showed no negative effects were caused by GMO products. A group of French scientists, however, decided to gather a research group and examine more closely  its effects by prolonging the study for up to four years. What they discovered was that although no initial side effects were seen in the tested animals, after the third year of the study, the ones that were fed with genetically-modified foods started developing tumors that affected more than 1/3 of their bodies.
The brain will entrain to the strongest stimulus. If you combine binaural beats with isochronic tones, your brainwaves will entrain to the isochronic tones. If anything, when you combine the two I believe it makes the track less effective because it makes it harder for the brain to decipher between the two and synchronise to a single beat. There are lots of websites with compelling marketing about the benefits of combining the two together in some funky way, but I haven’t seen any research or lots of anecdotal feedback even to suggest it’s effective to combine them.
My personal experience of this was that it could get very harrowing; at times, I would literally be gritting my teeth and contracting my ribs while I was in meditation, because it was pushing me so hard. I began to ask, “Is it necessary to push this hard in such a static way and create overwhelm over such prolonged periods in order to propel spiritual evolution?”
Transparent Corp's Research Area is arguably the most comprehensive resource for collated brainwave entrainment research.   Update: the main research area on Transparent Corp's website is currently being updated, so it is offline.  However, you can still access their peer-reviewed research paper as a PDF here: “A Comprehensive Review of the Psychological Effects of Brainwave Entrainment“.

Meanwhile, the therapeutic benefits of listening to sound and music is a well-established principle upon which the practice of receptive music therapy is founded. The term 'receptive music therapy' denotes a process by which patients or participants listen to music with specific intent to therapeutically benefit; and is a term used by therapists to distinguish it from 'active music therapy' by which patients or participants engage in producing vocal or instrumental music.[37] Receptive music therapy is an effective adjunctive intervention suitable for treating a range of physical and mental conditions.[38]

I’ve experienced all sorts of internal effects, ranging from feeling “high” to losing all awareness of my body, to seriously feeling like my head was turned completely backwards, only to just have to open my eyes to find it facing straight forward where I left it, to drifting into transcendent states of mind that can hardly even be described with words.
Theta brainwaves are next highest in frequency above delta and are especially important for many people using brainwave entrainment and meditation because theta waves are at a threshold, forming a link between wakefulness and the subconscious mind. Theta waves bridge between our awake self and the creative and insightful understandings from below our conscious awareness, and while they are not common in awake adults, they are normative for children under 13 years old. 
Theta brainwaves in the frequency range of 6 to 9 hertz are known as thalpha waves because of their proximity to alpha waves. They are seen during states of high suggestibility, during hypnosis, and during paranormal experience and are also connected to an increase in human growth hormone (HGH) levels and higher blood flow to the brain. Theta brainwaves sit between the realms of the subconscious and conscious mind, making them an especially useful brainwave state for developing creative thinking, working through emotional problems, and integrating subconscious and conscious experience. 
In BrainAscend, each brainwave frequency is stimulated for several minutes before progressing deeper.  Much like a staircase type of progression, but with small and smooth steps. This is the most effetive way and also stimulates the release of "feel good" brain chemicals such as serotonin which makes you feel happy. This chart shows the range that each level covers as well as the whole program.
One RCT (n=108) showed significant reduction in anxiety from a single session of alpha/delta therapy for day surgery patients. A crossover RCT of a single session of theta stimulation in four healthy adults reported significant improvement from the intervention in one of five measures. Five pre/post studies reported significant benefit from the intervention for 16 of 27 outcomes.
So if YOU’D like to begin meditating deeper than a Zen Monk... If YOU’D like to uncover why everyone says meditation is SO critical... If YOU’D like to discover the SHORTCUT to whole brain thinking and emotional happiness... If YOU’D like to gain insights into the universe... If YOU’D like to release the baggage you’ve been carrying around with you for so long... If YOU'D like to drop addictions and fears... If YOU’D like to become a happier individual, enjoying a natural LIFE HIGH 24/7...
Brainwave entrainment represents a way of using technology to take our meditation and our spiritual practices into territory that has previously been very difficult, if not impossible, for us to venture into. My inspiration for creating the Profound Meditation Program 3.0 was not about just adding binaural beats or isochronic tones to music, using conventional audio entrainment methods to create brainwave patterns, and say, “Hey, this is the next big thing!” To me, it is all about what we can do—even if it’s pulling from way outside of the box—to enable such a profound coherence that we can go to meditative depths that have been practically out of reach. With the Profound Meditation Program 3.0, I wanted to do something that hadn’t been done before, taking the technology to the next level.
One of the more fascinating aspects of what brainwave entrainment does, long-term, is the growing of your mental threshold, and your self-awareness.  I have been a participant of the Holosync Solution for several years, and its maker, Bill Harris, has gone to great lengths to explain why this technology does this.  Much of his research is based on the concept of Entropy and Open Systems, (an idea that nominated its discoverer for a nobel prize).  The brain being an open system, and the technology being a specific type of entropy, this technology has been shown to help the brain reorganize itself at a “higher level” through the growth of new neural pathways. This basically means that 
Recent research at the University of Lisbon finally uncovered the reason for the 350 year-old mystery, finding that the resonance of sound is the mechanism for entrainment of swinging pendulums and ticking clocks, and it seems likely that the energy transferred by sound is also responsible for other observations of entrainment, including brainwave entrainment.

I was not looking forward to returning back to my house as I live on my own so was very pleased to see that the “equisync” CDs had arrived in my absence. Ever since I have been back I put a CD on each evening and the change has been totally fantastic. The meditation is unbelievably calming and soothing, the inner-voice has been silenced and quite often I just put it on to drop off to sleep with the sound of gently falling rain. I can feel each day starting calmly and things like organising the memorial service have not been the strain and upset I would normally have expected. I could wax lyrical for hours because the benefits are truly and utterly fantastic. Never did I think I would find anything that would lift my spirits, clear my mind, calm the inner space but Equi-Sync has done that, and more.
After one month of using Equisync, I feel relaxed, calm and not stressed at all, despite that I am leaving my present job soon for an early retirement, I handle the situation very well. I have the feeling that I’m going to be ok and there is nothing to worry about. This is what I have gained so far from using Equisync and it’s really meaningful in the erratic world that we live in.
In fact, you can use an audio, as a beginner, that takes your brain to the same places that have been recorded in the brains of 30-year monastic Buddhist monks. When you start doing this, you begin to play around with “benefits” and “effects” that lie solely in the realm of consciousness itself. These benefits are also profound, yet not measurable or provable except through your own subjective experience.
It may be that you had the volume too loud, but I would expect you to hear the effects of that straight after you’ve stopped listening, not on a day you haven’t used them. It might be something similar to muscle memory, where you suddenly remembered the sound and sensations it gives you as if you were hearing it again. I don’t know how long you’ve been using this type of thing for, but maybe it’s something that will settle down and disappear once you become more accustomed to the sound.
It is a course that covers six months, after each month you move onto the next level of the program. The levels start off with the eye-opening Transcendence and move on to the literally mind expanding levels of Neptune’s Cave and Fusion. With each level you complete, your ability to solve problems and deal with stress goes through the roof, and you will feel a deep sense of emotional bliss.
Only 4 of the participants reported no change as a result of the stimulation. Four years later in a study (1989) by Anderson analyzed LED photic stimulation for the treatment of headaches. There were 60 patients included in the study which involved Variable Frequency Photo-stimulation (VFP) with specialized goggles that contained light-emitting diodes.
Hello Jason, this is an unusually thoughtful discussion. Thank you for all your expertise and your kind manner of presenting and moderating it. I’m wondering if you have any experience with this: ever since I’ve been exposed to theta wave music, without headphones, I have found it irritating. And this is in spite of the fact that when I was first handed a CD by someone I knew well and trusted he was so confident I’d love it It didn’t occur to either of us that I might not. This happened again recently, which is about 10 years later, when I heard it playing overhead at an acupuncture clinic. I felt restless and even irritated, unable to zone out, which is unusual for me, during the treatment. I realized that the quality of my irritation was similar to what I’d felt listening to that CD a decade ago.So I asked if it was theta wave music and she said yes. The acupuncturist said that some people, but a vast minority, really dislike the music. She said that the few people who dislike it are not simply neutral, but actively dislike it. And she also said, but most people like it a lot. I’m just wondering what kind of factors might be present that would make a person feel so irritated by this music?

If the further development of consciousness and awareness is your ultimate goal, there really is no substitute for actual meditation, of which many techniques are the result of thousands of years of human endeavor and accumulated knowledge and experience. Sure, it's not as easy as putting on headphones and pushing a button, but achieving authentic inner peace and relief from the stresses of human existence will mean so much more to you when earned through the time-tested route of traditional meditation. (Plus, once you learn to actually meditate, you can do it anywhere anytime without having to rely on being plugged in to something!)
Deeper Meditation • Near The Stage Of Sleep • Vivid, Dreamlike Imagery • Creative Visualization • Feel More Open & Connected • Advanced Problem Solving • Super Creativity • Insight • Intuition • Inspiration • Deeper Subconscious To Super-Conscious Mind • Trance-like • GABA • Immune System • Serotonin • Endorphins • Acetylcholine • Lower Cortisol • Deeply Relaxed • Sleep Better • Emotional Intelligence
The program uses special ‘brainwave’ sounds to meditate for you. That means you don’t have to actively try to quieten your mind, stop fidgeting, or focus only on the meditation. And you don’t have to reschedule your day. Each session lasts just 12 minutes, and you only need to meditate a few times a week to reap the rewards. Just sit back and hit play.
Subsequently, the term 'entrainment' has been used to describe a shared tendency of many physical and biological systems to synchronize their periodicity and rhythm through interaction. This tendency has been identified as specifically pertinent to the study of sound and music generally, and acoustic rhythms specifically. The most ubiquitous and familiar examples of neuromotor entrainment to acoustic stimuli is observable in spontaneous foot or finger tapping to the rhythmic beat of a song.
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