EquiSync’s design is based on the 100’s of studies performed on the effectiveness of brainwave entrainment technology, and 1000’s of studies on the powerful benefits of meditation. If you are interested in better understanding the power of this technology and rapidly expanding field of research, then here is a very abbreviated bibliography, a very small sample of the studies out there:
An important objective of entrainment is to produce a dissociative state, which is a meditation-like state of deep relaxation. It is the brain/body rehabilitative benefits produced by this deep trance-like state that makes AVE so useful for so many conditions. The dissociative state can be first observed by noticing deep and diaphragmatic breathing. Hands and feet become warmer as arteries dilate. Skin color will become pinker as blood flow increases throughout the face and body. Blood flow will increase in the brain as well. The person will experience feelings of profound relaxation and contentment as beneficial neurotransmitters are released into the brain. When in this deep state, the brain/body’s regenerative repair chemicals (parasympathetic hormones) and stabilizing neurotransmitters such as serotonin, endorphins and dopamine are released, which restore good brain function. AVE contributes to this restoration by providing a stress-break, increasing cerebral blood flow and encouraging impaired neuronal firing which allows the brain to return to normal function.
Monaural beats have similarities to binaural beats, but the two separate frequencies are delivered through a pulse pattern and mixed before they reach the listeners ears, resulting in the advantage of being audible without stereo headphones. However, using stereo headphones intensifies the effectiveness of monaural beats and is recommended for the best effect. 
This is a question I have noticed to concern many people, who are researching the issue. I have come across this question in forums, Yahoo Answers, in blogs, and all other sorts of  places. I can definitely empathize with someone who is looking to find a solution to a problem like anxiety, migraine, pain, etc., and needs reassurance and scientific proof that brainwave entrainment actually works!
Brainwave entrainment is a colloquialism for such 'neural entrainment', which is a term used to denote the way in which the aggregate frequency of oscillations produced by the synchronous electrical activity in ensembles of cortical neurons can adjust to synchronize with the periodic vibration of an external stimuli, such as a sustained acoustic frequency perceived as pitch, a regularly repeating pattern of intermittent sounds, perceived as rhythm, or of a regularly rhythmically intermittent flashing light.
Thanks Lorita. There hasn’t been any isochronic tones research that I’m aware of, for anti-aging, fat loss or attracting people, or any significant anecdotal feedback. You could combine positive affirmations or hypnosis scripts with isochronic tones to try and change habits and that could help with fat loss or build confidence to attract people. But it would be the affirmations and hypnosis doing most of the work, the isochronic tones would just be used to help relax the listener and put them in a more suggestible state. I don’t believe isochronic tones can affect those things, without being used in combination with some kind of vocal mental programming.
Binaural Beats or “binaural tones” are created by playing slightly different frequencies separately into each ear. The difference between the two frequencies stimulates a response in the brain which correlates with this frequency difference. For example, if we present a 100 Hz tone to the left ear and a 105 Hz tone to the right ear, a frequency of 5 Hz is stimulated. This is what is known as the “frequency following response”.

While a practical understanding of brainwaves has been around for as long as people have been singing, chanting, and drumming, a scientific view of the electrical activity inside the human brain was not published until 1924 when German psychiatrist Hans Berger developed a machine for sensing and recording activity in the brain by attaching small electrical sensors to the scalp of his patients and recording the resulting electrical activity. Berger’s inventions and discoveries were built upon the earlier work of Richard Caton who published animal studies on brainwave oscillations in 1875.
That is a general assumption people make but there isn’t really much science to back it up. What we do know though is that isochronic tones are ineffective below 4hz, and possibly a bit higher. So for theta and delta entrainment you are best off with binaural beats. In my experience binaural beats will be very effective all the way up to around 40hz.

I enjoy this one called: Cognition Enhancer For Clearer and Faster Thinking – Isochronic Tones (Electronic) … I seem to enjoy it. Any harm in just listening to this one every day for 30 minutes as a routine daily thing, just like brushing your teeth and making your bed. I would just use it at times when I’m working at my desk, maybe even reading the online news etc…Thoughts?
it says the following: “Running a delta sleep session throughout the night is not recommended as it can interrupt the normal sleep cycle”. I’ve been looping pure delta isochronic tones for about 5 days now, and have had quality sleep. Should I continue looping delta or should I let the videos play out without looping them? Will it will harm my health to do loop delta while I sleep?

Over the past few years, brainwave entrainment products have made a great rise in popularity, reaching more people than ever before and peaking their interest with the many benefits ensured. We now have a continually expanding pool of options to choose from, as well as more information and scientific research on the subject than in the past.  Brainwave Entrainment audios, and the products being made with this technology are literally changing the game in the personal development field, and have become one of the largest catalysts in our recent evolution as a human race.  In fact, these audios may be one of the main contributing factors in unlocking the potential to tap into the untouched 98% of our brains that we are currently not using.
Additionally, most of the studies have been conducted with extremely small samples and the touted benefits are vague. When studying the effects, it would be beneficial to hook each participant up to an EEG, note initial brainwave activity, then post-entrainment, note any changes. Although certain conditions share similarities in brainwave activity, this is clearly not always the case.
By exposing an individual to repeatedly external stimulus which can be flashing lights and/or recurring sounds, the entrainment process consists in pushing the brain to adjust to match the frequency provided. Unlike other forms of neurotherapy which require the individual to actively respond to stimulus, entrainment creates an immediate neurophysical response which is instinctive and effortless for the person being provided with the light and/or sound combinations. The key outcome of the sensory stimulation is known as the ‘Frequency Following Response’.

Absolutely. Binaural beats were first discovered over 150 years ago, and their use in brainwave entrainment audio has been the subject of a great deal of scientific exploration over the last 35 years in particular. Millions of people use brainwave entrainment music to enhance their quality of life and to experience deep relaxation. In fact, brainwave entrainment technology is now used for more than just meditation. It is also used by a variety of practitioners and private users for improving self-confidence, stress relief, pain management, relaxation, improving and concentration and improving the quality of one's sleep. If you would like to read an objective third party report on binaural beats, please refer to this Wikipedia article.
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If brainwave entrainment leaves you with unwanted side-effects (see below) or discomfort, you’re probably encouraging a range of brainwaves that are already excessive in some area of your brain. The way around this is to get a brain map to see what your brain’s strengths and weaknesses are, and see what (if any) brainwaves could use some encouragement. 
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