It is a good idea to follow any instructions outlined by the makers of any type of brainwave entrainment product or program, and to ease yourself carefully into using it. If experiencing any negative side effects, take a break and come back to it later. Brainwave entrainment audios are not recommended for children under the age of 18, and should not be used while driving or operating heavy machinery.
Your brain operates at certain levels of activity – the normal waking, active Beta, the meditative Alpha, the asleep-and-dreaming or deep meditative Theta, and the deep sleep/unconscious Delta. Beta is characterized by one thing we all want to get away from – stress.But that brainwave state has its place. It’s the action mode, and that’s the way it should be! If we’re not alert when we’re awake, bad things can happen, right?

Sleep improvement: There is significant anecdotal evidence that sleep induction and/or quality may be improved as a result of brainwave entrainment. While it is important to consider the placebo effect or simply the effect of a relaxing sound, many people have reported noticeable improvements in their ability to fall asleep and wake up feeling refreshed as a result of entrainment. Entraining frequencies within the slower wave ranges such as alpha, theta, or delta, may help individuals transition more quickly to those states.

So what happens when the mind is entrained with a sound or vibration that reflects the thought patterns? When the mind responds to certain frequencies and behaves as a resonator, [there] is a harmonic frequency that the mind can attune to … slower tempos have been proven to decrease heart and respiratory rates, thereby altering the predominant brain-wave patterns.
Brainwave entrainment is a field of study and endeavor founded in the same physiological and psychological processes that make music, drumming, and chanting so powerful as methods for transforming the mind and spirit and aiding in healing of the body. These processes involve how the electrical energy in our brains synchronizes with sounds and visual stimuli, producing a particular brainwave frequency and its associated mental states. 
Now next point to make here is that many of the other promised benefits of brainwave entrainment stem from this basic foundation.  For example, it has been said that listening to brainwave entrainment resets the brain’s sodium/potassium ratio, greatly decreasing mental fatigue, and improving the transporting of positive neurochemicals between brain cells.  This promise rests on the fact that it has been shown that this occurs while one is in the theta state. Therefore, the answer would be that yes, because these audios do lead one’s brain into the theta state, then it follows that they would promote the resetting of the brain’s sodium potassium ratio.
And don’t forget, the super-deep meditation and brain synchronization you’ll experience with Holosync® also creates some truly amazing changes in mental and emotional health. Anger, depression, sadness, anxiety, substance abuse, and a whole universe of dysfunctional feelings and behaviors fall away—even in people who have “tried everything” without success!
Normally, binaural beats, isochronic tones, or monaural tones have a certain level of capacity to entrain neural activity—and then they bottom out. By combining really great entrainment tools, I wanted to create a better entrainment stimulus that could entrain more neural activity quicker, allowing us to go deeper much more quickly than we have ever been able to go before, and moving our meditation practice or spiritual development to the next level.
Changes in neural oscillations, demonstrable through electroencephalogram (EEG) measurements, are precipitated by listening to music,[20][21][22][23][24][25] which can modulate autonomic arousal ergotropically and trophotropically, increasing and decreasing arousal respectively.[26] Musical auditory stimulation has also been demonstrated to improve immune function, facilitate relaxation, improve mood, and contribute to the alleviation of stress.[27][28][29][30][31][32][27][33] These findings have contributed to the development of neurologic music therapy, which uses music and song as an active and receptive intervention, to contribute to the treatment and management of disorders characterized by impairment to parts of the brain and central nervous system, including stroke, traumatic brain injury, Parkinson's disease, Huntington's disease, cerebral palsy, Alzheimer's disease, and autism.[34][35][36]
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